CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome
نویسندگان
چکیده
منابع مشابه
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP
Microinjection of human Jurkat T-lymphocytes with nicotinic acid adenine dinucleotide phosphate (NAADP 1 ) dose-dependently stimulated intracellular Ca 2 1 -signaling. At a concentration of 10 nM NAADP 1 evoked repetitive and long-lasting Ca 2 1 oscillations of low amplitude, whereas at 50 and 100 nM, a rapid and high initial Ca 2 1 -peak followed by trains of smaller Ca 2 1 -oscillations was o...
متن کاملNicotinic acid adenine dinucleotide phosphate (NAADP+).
Microinjection of human Jurkat T-lymphocytes with nicotinic acid adenine dinucleotide phosphate (NAADP 1 ) dose-dependently stimulated intracellular Ca 2 1 -signaling. At a concentration of 10 nM NAADP 1 evoked repetitive and long-lasting Ca 2 1 oscillations of low amplitude, whereas at 50 and 100 nM, a rapid and high initial Ca 2 1 -peak followed by trains of smaller Ca 2 1 -oscillations was o...
متن کاملCD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
In the present study, we have determined the role of the enzyme CD38 upon the synthesis of the Ca(2+)-releasing nucleotide nicotinic acid-adenine dinucleotide phosphate (NAADP). In rat tissues, we observed that the capacity for NAADP synthesis could be co-immunoprecipitated with CD38 using an anti-CD38 antibody. Furthermore, we observed that several tissues from CD38 knockout mice had no capaci...
متن کاملDetermination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels.
Nicotinic acid-adenine dinucleotide phosphate (NAADP) is fast emerging as a new intracellular Ca2+-mobilizing messenger. In sea urchin egg homogenates, binding of NAADP to its receptor is not readily reversible; hence, prior incubation with low concentrations of NAADP is more effective in inhibiting subsequent binding of radiolabelled NAADP than incubating the preparation with the two ligands s...
متن کاملNicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling*
Nicotinic acid adenine dinucleotide phosphate (NAADP)2 is a metabolite of NADP that was first identified as the most potent Ca2 stores mobilizing molecule in sea urchin egg homogenates more than a decade ago (1, 2). It has since been shown to be effective in a wide variety of cells, from plant to animal, including human (reviewed in Refs. 3–5). Its mechanism of action is distinct from those of ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2018
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.002113